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Target
Melatonin receptor type 1B
Ligand
BDBM463444
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
0.930±n/a nM
Citation
 Ruch Werneck Guimarães, C; Felype Zaneti De Azevedo, H; Mascarello, A; Watanabe Da Costa, R; Freire Torres Russo, V; Mannochio De Souza Russo, E Compounds, process for obtaining the compounds, pharmaceutical composition, use of the compounds and method for treating psychiatric disorders and/or sleep disorders US Patent  US11091445 Publication Date 8/17/2021 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Homo sapiens (Human)
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM463444
Synonyms:
US10781182, Compound IA2-121 | US11091445, Compound code IA2-121
Type:
Small organic molecule
Emp. Form.:
C14H18ClN3O3
Mol. Mass.:
311.764
SMILES:
CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O
Structure:
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