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Target
Non-receptor tyrosine-protein kinase TYK2 [833-1187]
Ligand
BDBM174006
Substrate
n/a
Meas. Tech.
TYK2 Kinase Assay
IC50
54±n/a nM
Citation
 Brasca, MG; Bindi, S; Caldarelli, M; Nesi, M; Orrenius, SC; Panzeri, A Substituted pyrroles active as kinases inhibitors US Patent  US9688661 Publication Date 6/27/2017 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [833-1187]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
40613.06
Organism:
Homo sapiens (Human)
Description:
Human TYK2 variant (833-1187 aa)
Residue:
355
Sequence:
LPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
  
Inhibitor
Name:
BDBM174006
Synonyms:
US9688661, 5-(6-Aminopyrimidin-4-yl)-2-[2-ethyl-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide (compd 218)
Type:
Small organic molecule
Emp. Form.:
C18H15F3N5O
Mol. Mass.:
374.3398
SMILES:
CCc1ccc(cc1-c1nc(cc1C(N)=O)-c1cc(N)ncn1)C(F)(F)F
Structure:
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