Reaction Details Report a problem with these data
Target
Glucokinase 1, putative
Ligand
BDBM514030
Substrate
n/a
Meas. Tech.
enzyme-inhibition screening assay
IC50
1190±n/a nM
Citation
 D''Antonio, E Monosaccharide amine and 3-nitro-2-phenyl-2H-chromene based inhibitors of glucose kinases US Patent  US11059842 Publication Date 7/13/2021 
Target
Name:
Glucokinase 1, putative
Synonyms:
Q4E4E1_TRYCC
Type:
Protein
Mol. Mass.:
41591.25
Organism:
Trypanosoma cruzi (strain CL Brener)
Description:
Q4E4E1
Residue:
376
Sequence:
MNIKELSLHELCEELKTPAWNVPLTFVGDVGGTSARMGFVREGKNDSVHACVTRYSMKRKDITELIEFFNEIIELMPASVIKRVKAGVINVPGPVTGGAVGGPFNNLKGIARLSDYPKALFPPGRSAILNDLEAGGFGVLAVSDAHVFSEYFGVMWEGTQWRTCEQEPAGSVIGRGRCLVLAPGTGLGSSLIYYNPMNQQHIVVPLELGSQTIPMRKDIDYIQTLHAELKLLPNYENMVSGAGLEFHYRQVVRGSRPPCSAGEIAKLASEGDANACKAMKKYHEYLMRVGSEASMALLPLTIVLVGDNIVNNAFFYRNPQNLKEMHREALNHEMERFGFQSRVTYLRQKKLLNLNLMGCYRCGLDLSVGKKQKAQL
  
Inhibitor
Name:
BDBM514030
Synonyms:
6-Bromo-2-(3,4-diethoxyphenyl)-3-nitro-2H-chromene | US11059842, Compound 24
Type:
Small organic molecule
Emp. Form.:
C19H18BrNO5
Mol. Mass.:
420.254
SMILES:
CCOc1ccc(cc1OCC)[C@@H]1Oc2ccc(Br)cc2C=C1[N+]([O-])=O |r,c:23|
Structure:
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