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Target
Protein-tyrosine kinase 6
Ligand
BDBM514121
Substrate
n/a
Meas. Tech.
Measurement of Brk Inhibitory Activity
IC50
7.00±n/a nM
Citation
 Yamamoto, S; Kurono, M; Yoshida, A; Hotta, S BRK inhibitory compound US Patent  US11052091 Publication Date 7/6/2021 
Target
Name:
Protein-tyrosine kinase 6
Synonyms:
BRK | Breast tumor kinase | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | PTK6 | PTK6_HUMAN | Protein-tyrosine kinase 6 (BRK) | Tyrosine Kinase BRK | Tyrosine-protein kinase 6 | Tyrosine-protein kinase BRK
Type:
Tyrosine-protein kinase
Mol. Mass.:
51839.11
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
451
Sequence:
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT
  
Inhibitor
Name:
BDBM514121
Synonyms:
US11052091, Example 1
Type:
Small organic molecule
Emp. Form.:
C23H22F2N8O3S
Mol. Mass.:
528.534
SMILES:
CC(C)(C)n1c2nc(Nc3ccc(cc3F)S(C)(=O)=O)nc(N)c2n(-c2ccc(F)c3[nH]ncc23)c1=O |(5.75,-4.6,;4.27,-4.2,;3.18,-5.29,;4.67,-5.69,;3.87,-2.71,;2.4,-2.23,;1.07,-3,;-.26,-2.23,;-1.6,-3,;-2.93,-2.23,;-2.93,-.69,;-4.26,.08,;-5.6,-.69,;-5.6,-2.23,;-4.26,-3,;-4.26,-4.54,;-6.93,.08,;-8.27,.85,;-6.93,1.62,;-8.27,-.69,;-.26,-.69,;1.07,.08,;1.07,1.62,;2.4,-.69,;3.87,-.22,;4.27,1.27,;3.24,2.41,;3.71,3.88,;5.22,4.2,;5.62,5.69,;6.25,3.05,;7.79,3.05,;8.27,1.59,;7.02,.68,;5.77,1.59,;4.77,-1.46,;6.31,-1.46,)|
Structure:
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