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Target
Synaptic vesicular amine transporter
Ligand
BDBM50301021
Substrate
n/a
Meas. Tech.
Determining Vmat2 Inhibitory Activity of a Compound
Ki
2.60±n/a nM
Citation
 Ashweek, N; Harriott, N [9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11BH-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto US Patent  US11053242 Publication Date 7/6/2021 
Target
Name:
Synaptic vesicular amine transporter
Synonyms:
Monoamine transporter | SLC18A2 | SVMT | Solute carrier family 18 member 2 | VAT2 | VMAT2 | VMAT2_HUMAN | Vesicular amine transporter 2
Type:
PROTEIN
Mol. Mass.:
55709.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_610810
Residue:
514
Sequence:
MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD
  
Inhibitor
Name:
BDBM50301021
Synonyms:
(+)-dihydrotetrabenzaine | CHEMBL576222 | US11053242, Compound R,R,R-DHTBZ
Type:
Small organic molecule
Emp. Form.:
C19H29NO3
Mol. Mass.:
319.4385
SMILES:
COc1cc2CCN3C[C@@H](CC(C)C)[C@H](O)C[C@@H]3c2cc1OC |r|
Structure:
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