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Target
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12
Ligand
BDBM87431
Substrate
n/a
Meas. Tech.
TR-Fret Assay
IC50
>67568±n/a nM
Citation
 Min, J; Scott, DC; Bhasin, D; Schulman, BA; Singh, B; Hammill, JT; Guy, RK Methods and compositions of inhibiting DCN1-UBC12 interaction US Patent  US11116757 Publication Date 9/14/2021 
Target
Name:
DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12
Synonyms:
DCN1-UBC12
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
NEDD8-conjugating enzyme Ubc12
Synonyms:
2.3.2.- | NEDD8 carrier protein | NEDD8-conjugating enzyme Ubc12 | UBC12 | UBC12_HUMAN | UBE2M | Ubiquitin-conjugating enzyme E2 M
Type:
PROTEIN
Mol. Mass.:
20901.74
Organism:
Homo sapiens
Description:
ChEMBL_118032
Residue:
183
Sequence:
MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNFKLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWKPVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFERCLK
  
Component 2
Name:
DCN1-like protein 1
Synonyms:
DCN1 | DCN1-like protein 1 | DCNL1_HUMAN | DCUN1 domain-containing protein 1 | DCUN1D1 | DCUN1L1 | Defective in cullin neddylation protein 1-like protein 1 | RP42 | SCCRO | Squamous cell carcinoma-related oncogene | Synonyms=DCN1
Type:
PROTEIN
Mol. Mass.:
30118.96
Organism:
Homo sapiens
Description:
ChEMBL_117443
Residue:
259
Sequence:
MNKLKSSQKDKVRQFMIFTQSSEKTAVSCLSQNDWKLDVATDNFFQNPELYIRESVKGSLDRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQEFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIAYWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLIDDFVEFARPQIAGTKSTTV
  
Inhibitor
Name:
BDBM87431
Synonyms:
MLS000708697 | N-(4-acetamidophenyl)-1-(2-thenoyl)isonipecotamide | N-(4-acetamidophenyl)-1-(thiophene-2-carbonyl)piperidine-4-carboxamide | N-(4-acetamidophenyl)-1-[oxo(thiophen-2-yl)methyl]-4-piperidinecarboxamide | N-(4-acetamidophenyl)-1-thiophen-2-ylcarbonyl-piperidine-4-carboxamide | SMR000289264 | US11116757, No. C35 | cid_1081265
Type:
Small organic molecule
Emp. Form.:
C19H21N3O3S
Mol. Mass.:
371.453
SMILES:
CC(=O)Nc1ccc(NC(=O)C2CCN(CC2)C(=O)c2cccs2)cc1
Structure:
Search PDB for entries with ligand similarity: