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Target
Bromodomain-containing protein 4 [342-460]
Ligand
BDBM518731
Substrate
n/a
Meas. Tech.
Plate-Based Time-Resolved Fluorescence Energy Transfer (TR-FRET) Assays
IC50
1050±n/a nM
Citation
 Zhou, J; Brasier, AR; Tian, B; Liu, Z; Chen, H; Rytting, E Inhibitors of bromodomain-containing protein 4 (BRD4) US Patent  US11117865 Publication Date 9/14/2021 
Target
Name:
Bromodomain-containing protein 4 [342-460]
Synonyms:
BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13783.81
Organism:
Homo sapiens (Human)
Description:
a.a. 342-460 (BRD4-BD2)
Residue:
119
Sequence:
PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM518731
Synonyms:
US11117865, Compound ZL0590
Type:
Small organic molecule
Emp. Form.:
C23H27F3N4O4S
Mol. Mass.:
512.545
SMILES:
FC(F)(F)c1ccc(NC(=O)Nc2ccc(cc2)S(=O)(=O)N2CCC[C@@H]2CN2CCOCC2)cc1 |r|
Structure:
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