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Target
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Ligand
BDBM519352
Substrate
n/a
Meas. Tech.
TarO Biochemical Enzymatic Assay
IC50
10.00±n/a nM
Citation
 Caldwell, JP; De Jesus, R; Ding, F; Gill, CJ; Ho, GD; Ha, SN; Koseoglu, SJ; Labroli, MA; Lee, SH; Madsen-Duggan, C; Mandal, M; Roemer, T; Su, J; Tan, CM; Tan, Z; Tang, H; Wang, H; Yang, C; Yang, S Oxazolidinones as taro inhibitors US Patent  US11141410 Publication Date 10/12/2021 
Target
Name:
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Synonyms:
GNPTA | GNPTAB | GNPTA_HUMAN | GlcNAc-1-phosphotransferase subunits alpha/beta | KIAA1208 | Stealth protein GNPTAB | UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Type:
Protein
Mol. Mass.:
143634.29
Organism:
Human
Description:
Q3T906
Residue:
1256
Sequence:
MLFKLLQRQTYTCLSHRYGLYVCFLGVVVTIVSAFQFGEVVLEWSRDQYHVLFDSYRDNIAGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVREQMEEEQKAMREILGKNTTEPTKKSEKQLECLLTHCIKVPMLVLDPALPANITLKDLPSLYPSFHSASDIFNVAKPKNPSTNVSVVVFDSTKDVEDAHSGLLKGNSRQTVWRGYLTTDKEVPGLVLMQDLAFLSGFPPTFKETNQLKTKLPENLSSKVKLLQLYSEASVALLKLNNPKDFQELNKQTKKNMTIDGKELTISPAYLLWDLSAISQSKQDEDISASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDVFRNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDFYSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCSGNSGGSRYIAGGGGTGSIGVGQPWQFGGGINSVSYCNQGCANSWLADKFCDQACNVLSCGFDAGDCGQDHFHELYKVILLPNQTHYIIPKGECLPYFSFAEVAKRGVEGAYSDNPIIRHASIANKWKTIHLIMHSGMNATTIHFNLTFQNTNDEEFKMQITVEVDTREGPKLNSTAQKGYENLVSPITLLPEAEILFEDIPKEKRFPKFKRHDVNSTRRAQEEVKIPLVNISLLPKDAQLSLNTLDLQLEHGDITLKGYNLSKSALLRSFLMNSQHAKIKNQAIITDETNDSLVAPQEKQVHKSILPNSLGVSERLQRLTFPAVSVKVNGHDQGQNPPLDLETTARFRVETHTQKTIGGNVTKEKPPSLIVPLESQMTKEKKITGKEKENSRMEENAENHIGVTEVLLGRKLQHYTDSYLGFLPWEKKKYFQDLLDEEESLKTQLAYFTDSKNTGRQLKDTFADSLRYVNKILNSKFGFTSRKVPAHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMSAVQPLNISQVFDEVDTDQSGVLSDREIRTLATRIHELPLSLQDLTGLEHMLINCSKMLPADITQLNNIPPTQESYYDPNLPPVTKSLVTNCKPVTDKIHKAYKDKNKYRFEIMGEEEIAFKMIRTNVSHVVGQLDDIRKNPRKFVCLNDNIDHNHKDAQTVKAVLRDFYESMFPIPSQFELPREYRNRFLHMHELQEWRAYRDKLKFWTHCVLATLIMFTIFSFFAEQLIALKRKIFPRRRIHKEASPNRIRV
  
Inhibitor
Name:
BDBM519352
Synonyms:
(4S,5R)-5-[3,5- bis(trifluoromethyl)phenyl]- 4-methyl-N-(1,6- naphthyridin-8- ylmethyl)-2-oxo-1,3- oxazolidine-3- carboxamide | US11141410, Example 4
Type:
Small organic molecule
Emp. Form.:
C22H16F6N4O3
Mol. Mass.:
498.3779
SMILES:
C[C@H]1[C@H](OC(=O)N1C(=O)NCc1cncc2cccnc12)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |r|
Structure:
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