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Target
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Ligand
BDBM519357
Substrate
n/a
Meas. Tech.
TarO Biochemical Enzymatic Assay
IC50
30.0±n/a nM
Citation
 Caldwell, JP; De Jesus, R; Ding, F; Gill, CJ; Ho, GD; Ha, SN; Koseoglu, SJ; Labroli, MA; Lee, SH; Madsen-Duggan, C; Mandal, M; Roemer, T; Su, J; Tan, CM; Tan, Z; Tang, H; Wang, H; Yang, C; Yang, S Oxazolidinones as taro inhibitors US Patent  US11141410 Publication Date 10/12/2021 
Target
Name:
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Synonyms:
GNPTA | GNPTAB | GNPTA_HUMAN | GlcNAc-1-phosphotransferase subunits alpha/beta | KIAA1208 | Stealth protein GNPTAB | UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Type:
Protein
Mol. Mass.:
143634.29
Organism:
Human
Description:
Q3T906
Residue:
1256
Sequence:
MLFKLLQRQTYTCLSHRYGLYVCFLGVVVTIVSAFQFGEVVLEWSRDQYHVLFDSYRDNIAGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVREQMEEEQKAMREILGKNTTEPTKKSEKQLECLLTHCIKVPMLVLDPALPANITLKDLPSLYPSFHSASDIFNVAKPKNPSTNVSVVVFDSTKDVEDAHSGLLKGNSRQTVWRGYLTTDKEVPGLVLMQDLAFLSGFPPTFKETNQLKTKLPENLSSKVKLLQLYSEASVALLKLNNPKDFQELNKQTKKNMTIDGKELTISPAYLLWDLSAISQSKQDEDISASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDVFRNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDFYSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCSGNSGGSRYIAGGGGTGSIGVGQPWQFGGGINSVSYCNQGCANSWLADKFCDQACNVLSCGFDAGDCGQDHFHELYKVILLPNQTHYIIPKGECLPYFSFAEVAKRGVEGAYSDNPIIRHASIANKWKTIHLIMHSGMNATTIHFNLTFQNTNDEEFKMQITVEVDTREGPKLNSTAQKGYENLVSPITLLPEAEILFEDIPKEKRFPKFKRHDVNSTRRAQEEVKIPLVNISLLPKDAQLSLNTLDLQLEHGDITLKGYNLSKSALLRSFLMNSQHAKIKNQAIITDETNDSLVAPQEKQVHKSILPNSLGVSERLQRLTFPAVSVKVNGHDQGQNPPLDLETTARFRVETHTQKTIGGNVTKEKPPSLIVPLESQMTKEKKITGKEKENSRMEENAENHIGVTEVLLGRKLQHYTDSYLGFLPWEKKKYFQDLLDEEESLKTQLAYFTDSKNTGRQLKDTFADSLRYVNKILNSKFGFTSRKVPAHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMSAVQPLNISQVFDEVDTDQSGVLSDREIRTLATRIHELPLSLQDLTGLEHMLINCSKMLPADITQLNNIPPTQESYYDPNLPPVTKSLVTNCKPVTDKIHKAYKDKNKYRFEIMGEEEIAFKMIRTNVSHVVGQLDDIRKNPRKFVCLNDNIDHNHKDAQTVKAVLRDFYESMFPIPSQFELPREYRNRFLHMHELQEWRAYRDKLKFWTHCVLATLIMFTIFSFFAEQLIALKRKIFPRRRIHKEASPNRIRV
  
Inhibitor
Name:
BDBM519357
Synonyms:
(4S,5R)-5-[3-fluoro-5- (trifluoromethyl)phenyl]- N-(2- methoxybenzyl)-4- methyl-2-oxo-1,3- oxazolidine-3- carboxamide | US11141410, Example 8
Type:
Small organic molecule
Emp. Form.:
C20H18F4N2O4
Mol. Mass.:
426.3615
SMILES:
COc1ccccc1CNC(=O)N1[C@@H](C)[C@H](OC1=O)c1cc(F)cc(c1)C(F)(F)F |r|
Structure:
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