Reaction Details Report a problem with these data
Target
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Ligand
BDBM519411
Substrate
n/a
Meas. Tech.
TarO Biochemical Enzymatic Assay
IC50
210±n/a nM
Citation
 Caldwell, JP; De Jesus, R; Ding, F; Gill, CJ; Ho, GD; Ha, SN; Koseoglu, SJ; Labroli, MA; Lee, SH; Madsen-Duggan, C; Mandal, M; Roemer, T; Su, J; Tan, CM; Tan, Z; Tang, H; Wang, H; Yang, C; Yang, S Oxazolidinones as taro inhibitors US Patent  US11141410 Publication Date 10/12/2021 
Target
Name:
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Synonyms:
GNPTA | GNPTAB | GNPTA_HUMAN | GlcNAc-1-phosphotransferase subunits alpha/beta | KIAA1208 | Stealth protein GNPTAB | UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Type:
Protein
Mol. Mass.:
143634.29
Organism:
Human
Description:
Q3T906
Residue:
1256
Sequence:
MLFKLLQRQTYTCLSHRYGLYVCFLGVVVTIVSAFQFGEVVLEWSRDQYHVLFDSYRDNIAGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVREQMEEEQKAMREILGKNTTEPTKKSEKQLECLLTHCIKVPMLVLDPALPANITLKDLPSLYPSFHSASDIFNVAKPKNPSTNVSVVVFDSTKDVEDAHSGLLKGNSRQTVWRGYLTTDKEVPGLVLMQDLAFLSGFPPTFKETNQLKTKLPENLSSKVKLLQLYSEASVALLKLNNPKDFQELNKQTKKNMTIDGKELTISPAYLLWDLSAISQSKQDEDISASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDVFRNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDFYSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCSGNSGGSRYIAGGGGTGSIGVGQPWQFGGGINSVSYCNQGCANSWLADKFCDQACNVLSCGFDAGDCGQDHFHELYKVILLPNQTHYIIPKGECLPYFSFAEVAKRGVEGAYSDNPIIRHASIANKWKTIHLIMHSGMNATTIHFNLTFQNTNDEEFKMQITVEVDTREGPKLNSTAQKGYENLVSPITLLPEAEILFEDIPKEKRFPKFKRHDVNSTRRAQEEVKIPLVNISLLPKDAQLSLNTLDLQLEHGDITLKGYNLSKSALLRSFLMNSQHAKIKNQAIITDETNDSLVAPQEKQVHKSILPNSLGVSERLQRLTFPAVSVKVNGHDQGQNPPLDLETTARFRVETHTQKTIGGNVTKEKPPSLIVPLESQMTKEKKITGKEKENSRMEENAENHIGVTEVLLGRKLQHYTDSYLGFLPWEKKKYFQDLLDEEESLKTQLAYFTDSKNTGRQLKDTFADSLRYVNKILNSKFGFTSRKVPAHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMSAVQPLNISQVFDEVDTDQSGVLSDREIRTLATRIHELPLSLQDLTGLEHMLINCSKMLPADITQLNNIPPTQESYYDPNLPPVTKSLVTNCKPVTDKIHKAYKDKNKYRFEIMGEEEIAFKMIRTNVSHVVGQLDDIRKNPRKFVCLNDNIDHNHKDAQTVKAVLRDFYESMFPIPSQFELPREYRNRFLHMHELQEWRAYRDKLKFWTHCVLATLIMFTIFSFFAEQLIALKRKIFPRRRIHKEASPNRIRV
  
Inhibitor
Name:
BDBM519411
Synonyms:
(4S,5R)-5-[3- fluoro-5- (trifluoromethyl) phenyl]-4- (hydroxymethyl)- N-(isoquinolin-4- ylmethyl)-2-oxo- 1,3-oxazolidine- 3-carboxamide | US11141410, Example 57
Type:
Small organic molecule
Emp. Form.:
C22H17F4N3O4
Mol. Mass.:
463.3817
SMILES:
OC[C@H]1[C@H](OC(=O)N1C(=O)NCc1cncc2ccccc12)c1cc(F)cc(c1)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: