Reaction Details Report a problem with these data
Target
L-lactate dehydrogenase B chain
Ligand
BDBM519573
Substrate
n/a
Meas. Tech.
Coupled Diaphorase Assay
IC50
75000±n/a nM
Citation
 Klaveness, J; Sieng, B; Lundvall, S; Bøen, CA; Hnida, K LDHA activity inhibitors US Patent  US11142520 Publication Date 10/12/2021 
Target
Name:
L-lactate dehydrogenase B chain
Synonyms:
L-lactate dehydrogenase B | L-lactate dehydrogenase B chain | LDH heart subunit | LDH-B | LDH-H | LDHB | LDHB_HUMAN | Lactate dehydrogenase B (LDHB) | Renal carcinoma antigen NY-REN-46
Type:
Oxidoreductase; homotetramer
Mol. Mass.:
36635.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
334
Sequence:
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
  
Inhibitor
Name:
BDBM519573
Synonyms:
US11142520, Example 28
Type:
Small organic molecule
Emp. Form.:
C30H30Cl2N2O4S2
Mol. Mass.:
617.606
SMILES:
CC(C)(C)C(=O)OC1=C(Sc2cc(Cl)ccc2Cl)C(=O)NC(C1)(c1ccsc1)c1ccc(cc1)N1CCOCC1 |c:7|
Structure:
Search PDB for entries with ligand similarity: