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Target
D-amino-acid oxidase
Ligand
BDBM210826
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Assay
IC50
12.0±n/a nM
Citation
 Farnaby, W; Fieldhouse, C; Hazel, K; Kerr, C; Kinsella, N; Livermore, D; Merchant, K; Miller, D Pyridazinone compounds and their use as DAAO inhibitors US Patent  US11129828 Publication Date 9/28/2021 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM210826
Synonyms:
US10463663, Example 66 | US11129828, Example 66 | US9290456, 66 | US9931340, Example 66
Type:
Small organic molecule
Emp. Form.:
C14H13F3N2O2
Mol. Mass.:
298.2604
SMILES:
Cc1cc(ccc1CCc1cc(O)c(=O)[nH]n1)C(F)(F)F
Structure:
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