Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM521443
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling
IC50
<100±n/a nM
Citation
 Grice, CA; Weber, OD; Buzard, DJ; Shaghafi, MB; Wiener, JJ; Cisar, JS; Duncan, KK Pyrazole MAGL inhibitors US Patent  US11149037 Publication Date 10/19/2021 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM521443
Synonyms:
N-(1-(1-((5- Chloro-1H- indol-2- yl)methyl)- 1,8-diazaspiro [4.5]decane-8- carbonyl)-1H- pyrazol-3- yl)acetamide | US11149037, Example 38
Type:
Small organic molecule
Emp. Form.:
C23H27ClN6O2
Mol. Mass.:
454.952
SMILES:
CC(=O)Nc1ccn(n1)C(=O)N1CCC2(CCCN2Cc2cc3cc(Cl)ccc3[nH]2)CC1
Structure:
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