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Target
Monoglyceride lipase
Ligand
BDBM521446
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling
IC50
<100±n/a nM
Citation
 Grice, CA; Weber, OD; Buzard, DJ; Shaghafi, MB; Wiener, JJ; Cisar, JS; Duncan, KK Pyrazole MAGL inhibitors US Patent  US11149037 Publication Date 10/19/2021 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM521446
Synonyms:
N-(1-((3aR, 5r,6aS)-5-((5- Chloro-2- (trifluoromethyl) benzyl)(methyl) amino)octa- hydrocyclopenta [c]pyrrole-2- carbonyl)-1H- pyrazol-3- yl)methane- sulfonamide | US11149037, Example 51
Type:
Small organic molecule
Emp. Form.:
C21H25ClF3N5O3S
Mol. Mass.:
519.968
SMILES:
CN(Cc1cc(Cl)ccc1C(F)(F)F)[C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)n1ccc(NS(C)(=O)=O)n1 |r|
Structure:
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