Reaction Details Report a problem with these data
Target
Fatty-acid amide hydrolase 1
Ligand
BDBM521456
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling
IC50
550±n/a nM
Citation
 Grice, CA; Weber, OD; Buzard, DJ; Shaghafi, MB; Wiener, JJ; Cisar, JS; Duncan, KK Pyrazole MAGL inhibitors US Patent  US11149037 Publication Date 10/19/2021 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM521456
Synonyms:
N-(1-(4-(3- (4-Chloro- phenoxy) benzyl) piperazine- 1-carbonyl)- 1H-pyrazol-3- yl)methane- sulfonamide | US11149037, Example 149
Type:
Small organic molecule
Emp. Form.:
C22H24ClN5O4S
Mol. Mass.:
489.975
SMILES:
CS(=O)(=O)Nc1ccn(n1)C(=O)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1
Structure:
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