Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM521502
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
44.0±n/a nM
Citation
 Dransfield, PJ; Harvey, JS; Ma, Z; Sharma, A Fused triazole agonists of the APJ receptor US Patent  US11149040 Publication Date 10/19/2021 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM521502
Synonyms:
US11149040, Example 32.0 | US11149040, Example 40.0 | US11149040, Example 41.0
Type:
Small organic molecule
Emp. Form.:
C22H29N7O5S
Mol. Mass.:
503.575
SMILES:
COC[C@@H]1COc2ncccc2-c2nnc(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c3ncc(C)cn3)n12 |r|
Structure:
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