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Target
Serine protease HTRA3 [111-436]
Ligand
BDBM521744
Substrate
n/a
Meas. Tech.
Chromogenic Enzyme Activity Assays
Ki
3100±600 nM
Citation
 Kaiser, M; Köcher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors US Patent  US11149067 Publication Date 10/19/2021 
Target
Name:
Serine protease HTRA3 [111-436]
Synonyms:
HTRA3 | HTRA3_HUMAN | High-temperature requirement factor A3 | PRSP | Pregnancy-related serine protease | Serine protease HTRA3 (aa 111-436)
Type:
Protein
Mol. Mass.:
35381.10
Organism:
Human
Description:
P83110[111-436]
Residue:
326
Sequence:
LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV
  
Inhibitor
Name:
BDBM521744
Synonyms:
US11149067, Compound Ahp3
Type:
Small organic molecule
Emp. Form.:
C54H72N8O12
Mol. Mass.:
1025.1959
SMILES:
CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@H](OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)c1ccccc1)C(C)C)C2=O |r|
Structure:
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