Reaction Details Report a problem with these data
Target
Serine protease HTRA2, mitochondrial
Ligand
BDBM521747
Substrate
n/a
Meas. Tech.
Chromogenic Enzyme Activity Assays
Ki
2100±300 nM
Citation
 Kaiser, M; Köcher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors US Patent  US11149067 Publication Date 10/19/2021 
Target
Name:
Serine protease HTRA2, mitochondrial
Synonyms:
HTRA2 | HTRA2_HUMAN | High temperature requirement protein A2 | OMI | Omi stress-regulated endoprotease | PRSS25 | Serine protease 25 | Serine protease HTRA2 (aa 138-458), mitochondrial | Serine proteinase OMI
Type:
Protein
Mol. Mass.:
48853.34
Organism:
Human
Description:
O43464[138-458]
Residue:
458
Sequence:
MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
  
Inhibitor
Name:
BDBM521747
Synonyms:
US11149067, Compound Ahp6
Type:
Small organic molecule
Emp. Form.:
C52H68N8O12
Mol. Mass.:
997.1427
SMILES:
CC(C)[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc2ccccc2)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2[C@H](O)CC[C@H](NC1=O)C2=O)C(C)C |r|
Structure:
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