Reaction Details Report a problem with these data
Target
Serine protease HTRA1 [158-480]
Ligand
BDBM521765
Substrate
n/a
Meas. Tech.
Chromogenic Enzyme Activity Assays
Ki
65.0±n/a nM
Citation
 Kaiser, M; Köcher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors US Patent  US11149067 Publication Date 10/19/2021 
Target
Name:
Serine protease HTRA1 [158-480]
Synonyms:
HTRA | HTRA1 | HTRA1_HUMAN | PRSS11 | Serine protease HTRA1 (aa 158-480)
Type:
Protein
Mol. Mass.:
35192.41
Organism:
Homo sapiens (Human)
Description:
Q92743[158-480]
Residue:
323
Sequence:
GQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
  
Inhibitor
Name:
BDBM521765
Synonyms:
US11149067, Compound Ahp26
Type:
Small organic molecule
Emp. Form.:
C52H65ClN8O12
Mol. Mass.:
1029.572
SMILES:
CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccc(Cl)cc2)N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC1=O)C1CC1)C2=O |r|
Structure:
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