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Target
Serine/threonine-protein kinase Nek7
Ligand
BDBM523002
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
400±n/a nM
Citation
 Bearss, DJ; Kauwe, III, JS; Mollard, AH Inhibitors of NEK7 kinase US Patent  US11161852 Publication Date 11/2/2021 
Target
Name:
Serine/threonine-protein kinase Nek7
Synonyms:
NEK kinase | NEK7 | NEK7_HUMAN
Type:
PROTEIN
Mol. Mass.:
34559.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586832
Residue:
302
Sequence:
MDEQSQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTASS
  
Inhibitor
Name:
BDBM523002
Synonyms:
1-(4-(4-amino-7-(1- methylpiperidin-4-yl)- 7H-pyrrolo[2,3- d]pyrimidin-5-yl)-2- fluorophenyl)-3-(3-(1- (trifluoromethyl)cyclopropyl)isoxazol- 5-yl)urea | US11161852, Compound 26 | US11713321, Example 26
Type:
Small organic molecule
Emp. Form.:
C26H26F4N8O2
Mol. Mass.:
558.5307
SMILES:
CN1CCC(CC1)n1cc(-c2ccc(NC(=O)Nc3cc(no3)C3(CC3)C(F)(F)F)c(F)c2)c2c(N)ncnc12
Structure:
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