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Target
Serine/threonine-protein kinase Nek7
Ligand
BDBM523008
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
1000±n/a nM
Citation
 Bearss, DJ; Kauwe, III, JS; Mollard, AH Inhibitors of NEK7 kinase US Patent  US11161852 Publication Date 11/2/2021 
Target
Name:
Serine/threonine-protein kinase Nek7
Synonyms:
NEK kinase | NEK7 | NEK7_HUMAN
Type:
PROTEIN
Mol. Mass.:
34559.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586832
Residue:
302
Sequence:
MDEQSQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTASS
  
Inhibitor
Name:
BDBM523008
Synonyms:
1-(4-(4-amino-7- cyclopropyl-7H- pyrrolo[2,3- d]pyrimidin-5-yl)-2- fluorophenyl)-3-(3- (hydroxymethyl)isoxazol- 5-yl)urea | US11161852, Compound 36 | US11713321, Example 36
Type:
Small organic molecule
Emp. Form.:
C20H18FN7O3
Mol. Mass.:
423.4004
SMILES:
Nc1ncnc2n(cc(-c3ccc(NC(=O)Nc4cc(CO)no4)c(F)c3)c12)C1CC1
Structure:
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