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Target
Tyrosine-protein kinase JAK1 [837-1142]
Ligand
BDBM344027
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
<100±n/a nM
Citation
 Li, Y; Zhu, W; Mei, S; Glenn, J Tricyclic fused thiophene derivatives as JAK inhibitors US Patent  US11161855 Publication Date 11/2/2021 
Target
Name:
Tyrosine-protein kinase JAK1 [837-1142]
Synonyms:
JAK1 | JAK1 (aa 837-1142) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142)
Type:
n/a
Mol. Mass.:
35230.04
Organism:
Homo sapiens (Human)
Description:
P23458[837-1142]
Residue:
306
Sequence:
FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF
  
Inhibitor
Name:
BDBM344027
Synonyms:
US10370387, Example 11 | US11161855, Example 11 | US9777017, Example 11 | US9908895, Example 11
Type:
Small organic molecule
Emp. Form.:
C17H21N3O2S
Mol. Mass.:
331.433
SMILES:
C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@H]1CC[C@H](CO)CC1 |r,wU:1.1,15.17,wD:18.21,(-3.93,.69,;-2.39,.69,;-1.62,2.02,;-1.62,-.64,;-2.25,-2.05,;-1.1,-3.08,;-1.1,-4.62,;.23,-5.39,;1.56,-4.62,;3.03,-5.1,;3.93,-3.85,;3.03,-2.6,;1.56,-3.08,;.23,-2.31,;-.09,-.8,;.68,.53,;-.41,1.62,;-.01,3.11,;1.48,3.5,;1.87,4.99,;3.36,5.39,;2.56,2.42,;2.17,.93,)|
Structure:
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