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Target
Tyrosine-protein kinase JAK1 [837-1142]
Ligand
BDBM344039
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
<100±n/a nM
Citation
 Li, Y; Zhu, W; Mei, S; Glenn, J Tricyclic fused thiophene derivatives as JAK inhibitors US Patent  US11161855 Publication Date 11/2/2021 
Target
Name:
Tyrosine-protein kinase JAK1 [837-1142]
Synonyms:
JAK1 | JAK1 (aa 837-1142) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142)
Type:
n/a
Mol. Mass.:
35230.04
Organism:
Homo sapiens (Human)
Description:
P23458[837-1142]
Residue:
306
Sequence:
FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF
  
Inhibitor
Name:
BDBM344039
Synonyms:
US10370387, Example 23 | US11161855, Example 23 | US9777017, Example 23
Type:
Small organic molecule
Emp. Form.:
C19H21N3OS
Mol. Mass.:
339.455
SMILES:
C[C@@H](O)c1cc2cnc3ccsc3c2n1[C@H]1CC[C@H](CC#N)CC1 |r,wU:1.1,15.17,wD:18.21,(-5.59,1.61,;-4.05,1.61,;-3.28,2.94,;-3.28,.28,;-3.9,-1.13,;-2.76,-2.16,;-2.76,-3.7,;-1.42,-4.47,;-.09,-3.7,;1.37,-4.18,;2.28,-2.93,;1.37,-1.69,;-.09,-2.16,;-1.42,-1.39,;-1.74,.12,;-.66,1.2,;-1.05,2.69,;.03,3.78,;1.52,3.38,;2.61,4.47,;4.1,4.07,;5.59,3.68,;1.92,1.89,;.83,.81,)|
Structure:
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