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Target
Tyrosine-protein kinase JAK1 [837-1142]
Ligand
BDBM523162
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
<100±n/a nM
Citation
 Li, Y; Zhu, W; Mei, S; Glenn, J Tricyclic fused thiophene derivatives as JAK inhibitors US Patent  US11161855 Publication Date 11/2/2021 
Target
Name:
Tyrosine-protein kinase JAK1 [837-1142]
Synonyms:
JAK1 | JAK1 (aa 837-1142) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142)
Type:
n/a
Mol. Mass.:
35230.04
Organism:
Homo sapiens (Human)
Description:
P23458[837-1142]
Residue:
306
Sequence:
FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF
  
Inhibitor
Name:
BDBM523162
Synonyms:
US11161855, Example 24 (first peak)
Type:
Small organic molecule
Emp. Form.:
C18H20N4O2S
Mol. Mass.:
356.442
SMILES:
C[C@@H](O)c1nc2cnc3ccsc3c2n1C1CC[C@@](O)(CC#N)CC1 |r,wU:1.1,18.21,wD:18.22,(-5.39,1.41,;-3.85,1.41,;-3.08,2.74,;-3.08,.08,;-3.7,-1.33,;-2.56,-2.36,;-2.56,-3.9,;-1.23,-4.67,;.11,-3.9,;1.57,-4.38,;2.48,-3.13,;1.57,-1.88,;.11,-2.36,;-1.23,-1.59,;-1.55,-.08,;-.46,1.01,;1.03,.61,;2.12,1.7,;1.72,3.18,;2.12,4.67,;3.21,3.58,;4.3,2.49,;5.39,1.4,;.23,3.58,;-.85,2.49,)|
Structure:
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