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Target
Tyrosine-protein kinase JAK2 [828-1132]
Ligand
BDBM344093
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
<100±n/a nM
Citation
 Li, Y; Zhu, W; Mei, S; Glenn, J Tricyclic fused thiophene derivatives as JAK inhibitors US Patent  US11161855 Publication Date 11/2/2021 
Target
Name:
Tyrosine-protein kinase JAK2 [828-1132]
Synonyms:
JAK2 | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (aa 828-1132)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35522.23
Organism:
Homo sapiens (Human)
Description:
aa 828-1132
Residue:
304
Sequence:
ALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM344093
Synonyms:
US10370387, Example 77 | US11161855, Example 77 | US9777017, Example 77 | US9908895, Example 77
Type:
Small organic molecule
Emp. Form.:
C17H20N4S
Mol. Mass.:
312.432
SMILES:
CC(=N)C(\[C@H]1CC[C@H](CC#N)CC1)=C1/NC=Nc2ccsc12 |r,wU:4.3,wD:7.7,c:16,(-4.82,1.61,;-4.05,.28,;-4.67,-1.13,;-2.51,.12,;-1.43,1.2,;-1.82,2.69,;-.74,3.78,;.75,3.38,;1.84,4.47,;3.33,4.07,;4.82,3.67,;1.15,1.89,;.06,.81,;-2.19,-1.39,;-3.53,-2.16,;-3.53,-3.7,;-2.19,-4.47,;-.86,-3.7,;.6,-4.18,;1.51,-2.93,;.6,-1.69,;-.86,-2.16,)|
Structure:
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