Reaction Details Report a problem with these data
Target
Cyclic AMP-dependent transcription factor ATF-4
Ligand
BDBM524116
Substrate
n/a
Meas. Tech.
Expression Inhibition Assay
IC50
18.8±n/a nM
Citation
 Delgado Oyarzo, LM; Ureta Díaz, GA; Pujala, B; Panpatil, D; Bernales, S; Chakravarty, S Inhibitors of integrated stress response pathway US Patent  US11166942 Publication Date 11/9/2021 
Target
Name:
Cyclic AMP-dependent transcription factor ATF-4
Synonyms:
ATF4 | ATF4_HUMAN | Activating transcription factor 4 | CREB-2 | CREB2 | Cyclic AMP-responsive element-binding protein 2 | TXREB | Tax-responsive enhancer element-binding protein 67 | TaxREB67 | cAMP-dependent transcription factor ATF-4 | cAMP-responsive element-binding protein 2
Type:
Protein
Mol. Mass.:
38573.48
Organism:
Human
Description:
P18848
Residue:
351
Sequence:
MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSEWLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTCDLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSLELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRGSPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKRAEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP
  
Inhibitor
Name:
BDBM524116
Synonyms:
US11166942, Compound 5
Type:
Small organic molecule
Emp. Form.:
C22H20Cl2FN3O4
Mol. Mass.:
480.316
SMILES:
Fc1cc(OCC(=O)NN2CCC(CC2)NC(=O)c2cc3cc(Cl)ccc3o2)ccc1Cl
Structure:
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