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Target
Chloride channel protein 2
Ligand
BDBM525290
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
1790±n/a nM
Citation
 Koster, AK; Du Bois, J; Maduke, MC Compositions and methods to modulate chloride ion channel activity US Patent  US11173137 Publication Date 11/16/2021 
Target
Name:
Chloride channel protein 2
Synonyms:
CLCN2 | CLCN2_HUMAN | ClC-2
Type:
Protein
Mol. Mass.:
98551.45
Organism:
Human
Description:
P51788
Residue:
898
Sequence:
MAAAAAEEGMEPRALQYEQTLMYGRYTQDLGAFAKEEAARIRLGGPEPWKGPPSSRAAPELLEYGRSRCARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQGLVEELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESAGIALRSLFCGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMSPEEILEWEEQQLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIEGSVTAQGVKVRPPLASFRDSATSSSDTETTEVHALWGPHSRHGLPREGSPSDSDDKCQ
  
Inhibitor
Name:
BDBM525290
Synonyms:
US11173137, Compound AK3-108B | US11173137, Compound FA35
Type:
Small organic molecule
Emp. Form.:
C13H9Cl2N2O2
Mol. Mass.:
296.129
SMILES:
Cc1ccc(Cl)c(Nc2ncccc2C([O-])=O)c1Cl
Structure:
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