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Target
Beta-adrenergic receptor kinase 2
Ligand
BDBM525316
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
0.048±n/a nM
Citation
 Shamloo, M; Jahangir, A; Yi, B; Evans, AK; Green, MJ Adrenergic receptor modulating compounds and methods of using the same US Patent  US11173144 Publication Date 11/16/2021 
Target
Name:
Beta-adrenergic receptor kinase 2
Synonyms:
ADRBK2 | ARBK2_HUMAN | BARK2 | GRK3
Type:
PROTEIN
Mol. Mass.:
79721.92
Organism:
Homo sapiens (Human)
Description:
ChEMBL_615172
Residue:
688
Sequence:
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKPRSGTVELPKPSLCHRNSNGL
  
Inhibitor
Name:
BDBM525316
Synonyms:
US11173144, Compound 69
Type:
Small organic molecule
Emp. Form.:
C20H22F3N3O2
Mol. Mass.:
393.4028
SMILES:
Cc1n[nH]c2cccc(OC[C@@H](O)CNCCc3ccccc3C(F)(F)F)c12 |r|
Structure:
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