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Target
Beta-adrenergic receptor kinase 2
Ligand
BDBM525321
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
0.380±n/a nM
Citation
 Shamloo, M; Jahangir, A; Yi, B; Evans, AK; Green, MJ Adrenergic receptor modulating compounds and methods of using the same US Patent  US11173144 Publication Date 11/16/2021 
Target
Name:
Beta-adrenergic receptor kinase 2
Synonyms:
ADRBK2 | ARBK2_HUMAN | BARK2 | GRK3
Type:
PROTEIN
Mol. Mass.:
79721.92
Organism:
Homo sapiens (Human)
Description:
ChEMBL_615172
Residue:
688
Sequence:
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKPRSGTVELPKPSLCHRNSNGL
  
Inhibitor
Name:
BDBM525321
Synonyms:
US11173144, Compound 55
Type:
Small organic molecule
Emp. Form.:
C21H27N3O5
Mol. Mass.:
401.4562
SMILES:
COc1ccc(OCCNC[C@H](O)COc2cccc3[nH]nc(C)c23)cc1OC |r|
Structure:
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