Reaction Details Report a problem with these data
Target
Taste receptor type 1 member 1/3
Ligand
BDBM526248
Substrate
n/a
Meas. Tech.
Activation of T1R1/T1R3 Receptor by Nucleotide Derivatives (alanine)
EC50
500±n/a nM
Citation
 McGrane, SJ; Taylor, AJ; Fine, RM; Klebansky, B; Gibbs, MR Methods for modulating taste receptors US Patent  US11185100 Publication Date 11/30/2021 
Target
Name:
Taste receptor type 1 member 1/3
Synonyms:
Taste Receptor T1R1/T1R3
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Taste receptor type 1 member 1
Synonyms:
GPR70 | T1R1 | TAS1R1 | TR1 | TS1R1_HUMAN | Taste receptor type 1 member 1 (T1R1)
Type:
Enzyme
Mol. Mass.:
93094.35
Organism:
Homo sapiens (Human)
Description:
Q7RTX1
Residue:
841
Sequence:
MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSSNQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQLLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIFKFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQRFPHLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTASVYDGKYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQASIQDYTRRCGST
  
Component 2
Name:
Taste receptor type 1 member 3
Synonyms:
T1R3 | TAS1R3 | TR3 | TS1R3_HUMAN | Taste receptor type 1 member 3 (T1R3)
Type:
Enzyme
Mol. Mass.:
93393.60
Organism:
Homo sapiens (Human)
Description:
Q7RTX0
Residue:
852
Sequence:
MLGPAVLGLSLWALLHPGTGAPLCLSQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTRFSSNGLLWALAMKMAVEEINNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKAGSRDIAAYCNYTQYQPRVLAVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRVQLTAAAELLQEFGWNWVAALGSDDEYGRQGLSIFSALAAARGICIAHEGLVPLPRADDSRLGKVQDVLHQVNQSSVQVVLLFASVHAAHALFNYSISSRLSPKVWVASEAWLTSDLVMGLPGMAQMGTVLGFLQRGAQLHEFPQYVKTHLALATDPAFCSALGEREQGLEEDVVGQRCPQCDCITLQNVSAGLNHHQTFSVYAAVYSVAQALHNTLQCNASGCPAQDPVKPWQLLENMYNLTFHVGGLPLRFDSSGNVDMEYDLKLWVWQGSVPRLHDVGRFNGSLRTERLKIRWHTSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDCVDCEAGSYRQNPDDIACTFCGQDEWSPERSTRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDSPLVQASGGPLACFGLVCLGLVCLSVLLFPGQPSPARCLAQQPLSHLPLTGCLSTLFLQAAEIFVESELPLSWADRLSGCLRGPWAWLVVLLAMLVEVALCTWYLVAFPPEVVTDWHMLPTEALVHCRTRSWVSFGLAHATNATLAFLCFLGTFLVRSQPGCYNRARGLTFAMLAYFITWVSFVPLLANVQVVLRPAVQMGALLLCVLGILAAFHLPRCYLLMRQPGLNTPEFFLGGGPGDAQGQNDGNTGNQGKHE
  
Inhibitor
Name:
BDBM526248
Synonyms:
US11185100, TABLE 9.1
Type:
Small organic molecule
Emp. Form.:
C10H15ClN5O7P
Mol. Mass.:
383.682
SMILES:
NC1=Nc2c(ncn2[C@@H]2O[C@H](COP(O)(O)=O)[C@H](O)C2O)C(Cl)N1 |r,t:1|
Structure:
Search PDB for entries with ligand similarity: