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Target
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Ligand
BDBM525977
Substrate
n/a
Meas. Tech.
Prolabel Quantification of IKZF1, IKZF2, or GSPT1 Protein Levels in 293GT Cells
EC50
>30000±n/a nM
Citation
 Beckwith, RE; Bonazzi, S; Cernijenko, A; Ma, F; Ware, NF 3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof US Patent  US11185537 Publication Date 11/30/2021 
Target
Name:
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Synonyms:
ERF3A | ERF3A_HUMAN | Eukaryotic peptide chain release factor subunit 3a | G1 to S phase transition protein 1 homolog | GSPT1
Type:
Protein
Mol. Mass.:
55745.21
Organism:
Human
Description:
P15170
Residue:
499
Sequence:
MELSEPIVENGETEMSPEESWEHKEEISEAEPGGGSLGDGRPPEESAHEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLKGIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD
  
Inhibitor
Name:
BDBM525977
Synonyms:
3-(5-(((1S,2S)-2- hydroxycyclohexyl)amino)-1- oxoisoindolin-2-yl)piperidine-2,6-dione | US11185537, Compound I-1
Type:
Small organic molecule
Emp. Form.:
C19H23N3O4
Mol. Mass.:
357.4036
SMILES:
O[C@H]1CCCC[C@@H]1Nc1ccc2C(=O)N(Cc2c1)C1CCC(=O)NC1=O |r|
Structure:
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