Reaction Details
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Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Ligand
BDBM526282
Substrate
n/a
Meas. Tech.
Prolabel Quantification of IKZF1, IKZF2, or GSPT1 Protein Levels in 293GT Cells
EC50
>50000±n/a nM
Citation
Beckwith, RE; Bonazzi, S; Cernijenko, A; Ma, F; Ware, NF 3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof US Patent US11185537 Publication Date 11/30/2021 More Info.:
Target
Name:
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Synonyms:
ERF3A | ERF3A_HUMAN | Eukaryotic peptide chain release factor subunit 3a | G1 to S phase transition protein 1 homolog | GSPT1
Type:
Protein
Mol. Mass.:
55745.21
Organism:
Human
Description:
P15170
Residue:
499
Sequence:
MELSEPIVENGETEMSPEESWEHKEEISEAEPGGGSLGDGRPPEESAHEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLKGIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD
Inhibitor
Name:
BDBM526282
Synonyms:
5-(((1S,2S)-2- (dimethylamino)cyclohexyl)amino)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3-dione | US11185537, Compound I-153
Type:
Small organic molecule
Emp. Form.:
C21H26N4O4
Mol. Mass.:
398.4555
SMILES:
CN(C)[C@H]1CCCC[C@@H]1Nc1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1 |r|
Structure:
