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Target
Somatostatin receptor type 2
Ligand
BDBM449019
Substrate
n/a
Meas. Tech.
cAMP Assay of SSTR2
EC50
<0.1±n/a nM
Citation
 Han, S; Kim, SH; Zhu, Y Somatostatin modulators and uses thereof US Patent  US11186590 Publication Date 11/30/2021 
Target
Name:
Somatostatin receptor type 2
Synonyms:
SOMATOSTATIN SST2 | SRIF-1 | SS-2-R | SS2-R | SS2R | SSR2_HUMAN | SSTR2 | Somatostatin receptor type 2 (SSTR2)
Type:
Enzyme
Mol. Mass.:
41344.94
Organism:
Homo sapiens (Human)
Description:
P30874
Residue:
369
Sequence:
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
  
Inhibitor
Name:
BDBM449019
Synonyms:
2-{4-[(4αS,8αS)-octahydro-1H-pyrido[3,4-b][1,4]oxazin-6-yl]-2-amino-5-(3-fluoro-5-methylphenyl)pyridin-3-yl}-4-methoxy-1H-1,3-benzodiazole-6-carbonitrile | US10696689, Compound 3-16 | US11186590, Compound 3-16
Type:
Small organic molecule
Emp. Form.:
C28H28FN7O2
Mol. Mass.:
513.566
SMILES:
COc1cc(cc2[nH]c(nc12)-c1c(N)ncc(-c2cc(C)cc(F)c2)c1N1CC[C@@H]2NCCO[C@H]2C1)C#N |r|
Structure:
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