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Target
Plasma serine protease inhibitor
Ligand
BDBM528102
Substrate
n/a
Meas. Tech.
Determination of Enzyme Selectivity
IC50
>40000±n/a nM
Citation
 Davie, RL; Edwards, HJ; Evans, DM; Hodgson, ST; Pethen, SJ; Rooker, DP Pyrazole derivatives as plasma kallikrein inhibitors US Patent  US11180484 Publication Date 11/23/2021 
Target
Name:
Plasma serine protease inhibitor
Synonyms:
Acrosomal serine protease inhibitor | Plasminogen activator inhibitor 3 | Protein C inhibitor | Serpin A5 | PAI-3 | PAI3 | IPSP_HUMAN | SERPINA5 | PCI | PLANH3 | PROCI
Type:
Protein
Mol. Mass.:
45687.25
Organism:
Human
Description:
P05154
Residue:
406
Sequence:
MQLFLLLCLVLLSPQGASLHRHHPREMKKRVEDLHVGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNNILFLGKVNRP
  
Inhibitor
Name:
BDBM528102
Synonyms:
3-amino-N-[(2,6-difluoro-3-methoxyphenyl)methyl]-1-({4-[(2-oxopyridin-1- yl)methyl]phenyl}methyl)pyrazole-4-carboxamide | US11180484, Example 35
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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