Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM530924
Substrate
n/a
Meas. Tech.
Enzyme Activity: Determination of IC50
IC50
0.450±n/a nM
Citation
Pasternak, A; Dong, S; Scott, JD; Tang, H; Zhao, Z; Yang, D; Gu, X; Jiang, J; Xiao, L Metallo-beta-lactamase inhibitors and methods of use thereof US Patent US11207312 Publication Date 12/28/2021
More Info.:
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
Inhibitor
Name:
BDBM530924
Synonyms:
6-(azetidin-3-ylsulfonyl)-3-[4- (2-hydroxyethyl)piperidin-1- yl]-2-(1H-tetrazol-5- yl)benzenesulfonamide | US11207312, Example 56
Type:
Small organic molecule
Emp. Form.:
C17H25N7O5S2
Mol. Mass.:
471.554
SMILES:
NS(=O)(=O)c1c(ccc(N2CCC(CCO)CC2)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1