Reaction Details Report a problem with these data
Target
Histone deacetylase 3
Ligand
BDBM323718
Substrate
n/a
Meas. Tech.
IC50 Assay
IC50
23.0±n/a nM
Citation
 Hooker, J; Wang, C; Strebl-Bantillo, MG HDAC6 inhibitors and imaging agents US Patent  US11207431 Publication Date 12/28/2021 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM323718
Synonyms:
US10188756, Compound CN149 | US11207431, Example B
Type:
Small organic molecule
Emp. Form.:
C22H29FN2O2
Mol. Mass.:
372.4763
SMILES:
CN(Cc1ccc(\C=C\C(=O)NO)cc1F)CC12CC3CC(CC(C3)C1)C2 |TLB:20:21:25:19.24.18,24:19:26:25.23.22,24:23:26:19.20.18,THB:20:19:25:26.21.22|
Structure:
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