Reaction Details Report a problem with these data
Target
CAM kinase, CDPK family TgCDPK1
Ligand
BDBM50250014
Substrate
n/a
Meas. Tech.
Expression and Purification of Active Kinases
IC50
3.38±n/a nM
Citation
 Rutaganira, F; Shokat, KM; Sibley, LD; Janetka, JW Compositions and methods for treating parasitic diseases US Patent  US11208411 Publication Date 12/28/2021 
Target
Name:
CAM kinase, CDPK family TgCDPK1
Synonyms:
TgCDPK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57248.42
Organism:
Toxoplasma gondii (strain ATCC 50861 / VEG)
Description:
n/a
Residue:
507
Sequence:
MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNGYIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVDKNNDGEVDFDEFQQMLLKLCGN
  
Inhibitor
Name:
BDBM50250014
Synonyms:
CHEMBL2324597 | US11208411, Compound 3CIB-PP1
Type:
Small organic molecule
Emp. Form.:
C16H18ClN5
Mol. Mass.:
315.801
SMILES:
CC(C)(C)n1nc(Cc2cccc(Cl)c2)c2c(N)ncnc12
Structure:
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