Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM377218
Substrate
n/a
Meas. Tech.
Pim Enzyme Assay
IC50
<100±n/a nM
Citation
 Xue, CLi, YFeng, HPan, JWang, AZhang, KYao, WZhang, FZhuo, J Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors US Patent  US11229631 Publication Date 1/25/2022 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM377218
Synonyms:
US10265307, Example 56-2 | US10517858, Example 56 (Diastereoisomer 2) | US10828290, Example 56 (Diastereoisomer 2) | US11229631, Example 56 Diastereoisomer 2
Type:
Small organic molecule
Emp. Form.:
C27H28F3N5O3
Mol. Mass.:
527.5381
SMILES:
COc1ccc(F)c(c1F)-c1nc(ccc1F)C(=O)Nc1cnc2[C@H](O)CCc2c1N1C[C@H](C)C[C@H](N)C1 |r,wU:35.39,32.36,wD:24.26,(7.19,4.83,;5.85,5.6,;4.52,4.83,;3.19,5.6,;1.85,4.83,;1.85,3.29,;.52,2.52,;3.19,2.52,;4.52,3.29,;5.85,2.52,;3.19,.98,;1.85,.21,;1.85,-1.33,;3.19,-2.1,;4.52,-1.33,;4.52,.21,;5.85,.98,;.52,-2.1,;.52,-3.64,;-.82,-1.33,;-2.15,-2.1,;-2.15,-3.64,;-3.48,-4.41,;-4.82,-3.64,;-6.28,-4.11,;-6.68,-5.6,;-7.19,-2.87,;-6.28,-1.62,;-4.82,-2.1,;-3.48,-1.33,;-3.48,.21,;-2.15,.98,;-2.15,2.52,;-.82,3.29,;-3.48,3.29,;-4.82,2.52,;-6.15,3.29,;-4.82,.98,)|
Structure:
Search PDB for entries with ligand similarity: