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Target
Uromodulin
Ligand
BDBM534908
Substrate
n/a
Meas. Tech.
In-Vitro Assay
IC50
63.0±n/a nM
Citation
 Sharma, R; Iyer, P; Agarwal, S Substituted sulfoximine compounds US Patent  US11236045 Publication Date 2/1/2022 
Target
Name:
Uromodulin
Synonyms:
THP | Tamm-Horsfall urinary glycoprotein | UMOD | UROM_HUMAN
Type:
Protein
Mol. Mass.:
69744.65
Organism:
Human
Description:
P07911
Residue:
640
Sequence:
MGQPSLTWMLMVVVASWFITTAATDTSEARWCSECHSNATCTEDEAVTTCTCQEGFTGDGLTCVDLDECAIPGAHNCSANSSCVNTPGSFSCVCPEGFRLSPGLGCTDVDECAEPGLSHCHALATCVNVVGSYLCVCPAGYRGDGWHCECSPGSCGPGLDCVPEGDALVCADPCQAHRTLDEYWRSTEYGEGYACDTDLRGWYRFVGQGGARMAETCVPVLRCNTAAPMWLNGTHPSSDEGIVSRKACAHWSGHCCLWDASVQVKACAGGYYVYNLTAPPECHLAYCTDPSSVEGTCEECSIDEDCKSNNGRWHCQCKQDFNITDISLLEHRLECGANDMKVSLGKCQLKSLGFDKVFMYLSDSRCSGFNDRDNRDWVSVVTPARDGPCGTVLTRNETHATYSNTLYLADEIIIRDLNIKINFACSYPLDMKVSLKTALQPMVSALNIRVGGTGMFTVRMALFQTPSYTQPYQGSSVTLSTEAFLYVGTMLDGGDLSRFALLMTNCYATPSSNATDPLKYFIIQDRCPHTRDSTIQVVENGESSQGRFSVQMFRFAGNYDLVYLHCEVYLCDTMNEKCKPTCSGTRFRSGSVIDQSRVLNLGPITRKGVQATVSRAFSSLGLLKVWLPLLLSATLTLTFQ
  
Inhibitor
Name:
BDBM534908
Synonyms:
US11236045, Example 44
Type:
Small organic molecule
Emp. Form.:
C20H18F2N4O2S
Mol. Mass.:
416.444
SMILES:
Fc1cc(F)cc(c1)S(=O)(NC(=O)Nc1c2CCCc2cc2CCCc12)=NC#N
Structure:
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