Reaction Details Report a problem with these data
Target
Flap endonuclease 1
Ligand
BDBM538210
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
9.40±n/a nM
Citation
 Gahman, T; Shiau, A; Kolodner, R 3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators US Patent  US11253521 Publication Date 2/22/2022 
Target
Name:
Flap endonuclease 1
Synonyms:
DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Type:
PROTEIN
Mol. Mass.:
42602.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517026
Residue:
380
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGSTKKKAKTGAAGKFKRGK
  
Inhibitor
Name:
BDBM538210
Synonyms:
US11253521, No. 80
Type:
Small organic molecule
Emp. Form.:
C16H14N2O6S
Mol. Mass.:
362.357
SMILES:
COc1ccc(c2[nH]c(=O)n(O)c(=O)c12)S(=O)(=O)c1cccc(C)c1
Structure:
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