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Target
GTPase NRas
Ligand
BDBM538640
Substrate
n/a
Meas. Tech.
AlphaLISA Assay
IC50
4290±n/a nM
Citation
 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors US Patent  US11254667 Publication Date 2/22/2022 
Target
Name:
GTPase NRas
Synonyms:
HRAS1 | NRAS | RASN_HUMAN | Transforming protein N-Ras
Type:
PROTEIN
Mol. Mass.:
21223.91
Organism:
Homo sapiens (Human)
Description:
ChEMBL_839699
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM
  
Inhibitor
Name:
BDBM538640
Synonyms:
NCGC 00249356 | US11254667, Compound I-45 | US11542261, Compound I-45
Type:
Small organic molecule
Emp. Form.:
C18H17N7
Mol. Mass.:
331.3745
SMILES:
C1NCC1Nc1cccc(n1)-c1cnc2ccc(cn12)-c1cn[nH]c1
Structure:
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