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Target
Non-receptor tyrosine-protein kinase TYK2
Ligand
BDBM539079
Substrate
n/a
Meas. Tech.
JAK Caliper Enzyme Assay at 1mM ATP
IC50
12.0±n/a nM
Citation
 Gerstenberger, BS; Fensome, A; Owen, DR; Brown, MF; Hayward, MM; Vajdos, F; Xing, LH; Wright, SW Pyrazolo[1,5-A]pyrazin-4-yl and related derivatives US Patent  US11254668 Publication Date 2/22/2022 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2
Type:
Protein
Mol. Mass.:
133666.03
Organism:
Homo sapiens (Human)
Description:
P29597
Residue:
1187
Sequence:
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
  
Inhibitor
Name:
BDBM539079
Synonyms:
US11254668, Example 425 | US11254668, Example 426
Type:
Small organic molecule
Emp. Form.:
C26H20N8O2
Mol. Mass.:
476.4894
SMILES:
CN1C(=O)COc2ccc(nc12)-c1cc(-c2cnn(n2)C2(CC#N)CC(C2)C#N)c2cccnc2c1 |(5.33,-4.62,;5.33,-3.08,;6.67,-2.31,;8,-3.08,;6.67,-.77,;5.33,,;4,-.77,;2.67,,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;,-3.08,;,-4.62,;-1.33,-5.39,;-1.33,-6.93,;-2.58,-7.84,;-2.1,-9.3,;-.56,-9.3,;-.09,-7.84,;.34,-10.55,;-.9,-11.45,;-.74,-12.98,;-.58,-14.51,;1.59,-9.64,;2.49,-10.89,;1.25,-11.79,;4.01,-11.13,;5.53,-11.37,;-2.67,-4.62,;-4,-5.39,;-5.33,-4.62,;-5.33,-3.08,;-4,-2.31,;-2.67,-3.08,;-1.33,-2.31,)|
Structure:
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