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Target
Programmed cell death 1 ligand 1
Ligand
BDBM541136
Substrate
n/a
Meas. Tech.
Enzyme-Linked Immunosorbent Assay ELISA
IC50
5500±n/a nM
Citation
 Fan, P; Lange, C; Mali, VR; McMurtrie, DJ; Malathong, V; Punna, S; Singh, R; Yang, J; Zeng, Y; Zhang, P Triaryl compounds for treatment of PD-L1 diseases US Patent  US11266643 Publication Date 3/8/2022 
Target
Name:
Programmed cell death 1 ligand 1
Synonyms:
B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1
Type:
PROTEIN
Mol. Mass.:
33278.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109807
Residue:
290
Sequence:
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
  
Inhibitor
Name:
BDBM541136
Synonyms:
US11266643, Compound 1.304
Type:
Small organic molecule
Emp. Form.:
C27H25FN4O4
Mol. Mass.:
488.5102
SMILES:
COc1cc(cc(F)c1CN)-c1cccc(c1C)-c1cccc(NC(=O)c2cc([nH]n2)C(O)=O)c1C
Structure:
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