Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 1
Ligand
BDBM541754
Substrate
n/a
Meas. Tech.
Inhibitory Activities Assay
IC50
<20±n/a nM
Citation
 Wang, H Class of amino-substituted nitrogen-containing fused ring compounds, preparation method therefor, and use thereof US Patent  US11267815 Publication Date 3/8/2022 
Target
Name:
Fibroblast growth factor receptor 1
Synonyms:
BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr
Type:
Receptor
Mol. Mass.:
91861.70
Organism:
Homo sapiens (Human)
Description:
P11362
Residue:
822
Sequence:
MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
  
Inhibitor
Name:
BDBM541754
Synonyms:
US11267815, Example 7
Type:
Small organic molecule
Emp. Form.:
C34H43Cl2N9O3
Mol. Mass.:
696.67
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCN3CCN(C)CC3)nc2n2cc(CCCN3CCN(CC3)C(=O)C=C)nc12 |(5.33,10.69,;6.67,9.92,;6.67,8.38,;8,7.61,;8,6.07,;9.34,5.3,;10.67,6.07,;6.67,5.3,;6.67,3.76,;5.33,6.07,;5.33,7.61,;4,8.38,;4,5.3,;2.67,6.07,;1.33,5.3,;,6.07,;-1.33,5.3,;-1.33,3.76,;-2.67,2.99,;-4,3.76,;-5.33,2.99,;-6.67,3.76,;-6.67,5.3,;-8,6.07,;-9.34,5.3,;-10.67,6.07,;-9.34,3.76,;-8,2.99,;,2.99,;1.33,3.76,;2.67,2.99,;2.99,1.48,;4.52,1.32,;5.29,-.02,;4.52,-1.35,;5.29,-2.68,;4.52,-4.02,;5.29,-5.35,;4.52,-6.68,;2.98,-6.68,;2.21,-5.35,;2.98,-4.02,;2.21,-8.02,;.67,-8.02,;2.98,-9.35,;2.21,-10.69,;5.15,2.72,;4,3.76,)|
Structure:
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