Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 1
Ligand
BDBM541757
Substrate
n/a
Meas. Tech.
Inhibitory Activities Assay
IC50
<20±n/a nM
Citation
 Wang, H Class of amino-substituted nitrogen-containing fused ring compounds, preparation method therefor, and use thereof US Patent  US11267815 Publication Date 3/8/2022 
Target
Name:
Fibroblast growth factor receptor 1
Synonyms:
BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr
Type:
Receptor
Mol. Mass.:
91861.70
Organism:
Homo sapiens (Human)
Description:
P11362
Residue:
822
Sequence:
MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
  
Inhibitor
Name:
BDBM541757
Synonyms:
US11267815, Example 10
Type:
Small organic molecule
Emp. Form.:
C30H35Cl2N7O5
Mol. Mass.:
644.549
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC(O)CO)nc2n2cc(CCCN3CCN(CC3)C(=O)C=C)nc12 |(4,10.69,;5.33,9.92,;5.33,8.38,;6.67,7.61,;6.67,6.07,;8,5.3,;9.34,6.07,;5.33,5.3,;5.33,3.76,;4,6.07,;4,7.61,;2.67,8.38,;2.67,5.3,;1.33,6.07,;,5.3,;-1.33,6.07,;-2.67,5.3,;-2.67,3.76,;-4,2.99,;-5.33,3.76,;-6.67,2.99,;-6.67,1.45,;-8,3.76,;-9.34,2.99,;-1.33,2.99,;,3.76,;1.33,2.99,;1.65,1.48,;3.19,1.32,;3.96,-.02,;3.19,-1.35,;3.96,-2.68,;3.19,-4.02,;3.96,-5.35,;3.19,-6.68,;1.65,-6.68,;.88,-5.35,;1.65,-4.02,;.88,-8.02,;-.66,-8.02,;1.65,-9.35,;.88,-10.69,;3.81,2.72,;2.67,3.76,)|
Structure:
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