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Target
Tryptophan 2,3-dioxygenase
Ligand
BDBM541856
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
11.6±n/a nM
Citation
 Boss, C; Bur, D; Cren, S; Kimmerlin, T; Lotz-Jenne, C; Pothier, J; Tidten-Luksch, N Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase US Patent  US11267824 Publication Date 3/8/2022 
Target
Name:
Tryptophan 2,3-dioxygenase
Synonyms:
T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase
Type:
PROTEIN
Mol. Mass.:
47874.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_825691
Residue:
406
Sequence:
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
  
Inhibitor
Name:
BDBM541856
Synonyms:
US11267824, Example 68a
Type:
Small organic molecule
Emp. Form.:
C14H18N2OS
Mol. Mass.:
262.371
SMILES:
O[C@@H](C1CCCCC1)c1c(C=C)sc2cncn12 |r|
Structure:
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