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Target
Anoctamin-2
Ligand
BDBM542066
Substrate
n/a
Meas. Tech.
Inhibition of ANO1 Over ANO2
IC50
13100±70 nM
Citation
 Namkung, W; Kim, IY; Seo, Y; Kim, JH Pharmaceutical composition for ANO1 antagonist with anticancer activity US Patent  US11274074 Publication Date 3/15/2022 
Target
Name:
Anoctamin-2
Synonyms:
ANO2 | ANO2_HUMAN | Anoctamin-2 | C12orf3 | TMEM16B | Transmembrane protein 16B
Type:
PROTEIN
Mol. Mass.:
113968.03
Organism:
Homo sapiens
Description:
ChEMBL_117372
Residue:
1003
Sequence:
MATPGPRDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGESTRSSSVINNYLDANEPVSLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAEFLKIKVPTKKEMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMSSGSQHTNV
  
Inhibitor
Name:
BDBM542066
Synonyms:
US11274074, Example 11 [Chemical Formula 15]
Type:
Small organic molecule
Emp. Form.:
C17H18ClNO3
Mol. Mass.:
319.783
SMILES:
COc1ccccc1CNC(=O)COc1ccc(Cl)cc1C
Structure:
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