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Target
Anoctamin-2
Ligand
BDBM50503433
Substrate
n/a
Meas. Tech.
Inhibition of ANO1 Over ANO2
IC50
>100000±n/a nM
Citation
 Namkung, W; Kim, IY; Seo, Y; Kim, JH Pharmaceutical composition for ANO1 antagonist with anticancer activity US Patent  US11274074 Publication Date 3/15/2022 
Target
Name:
Anoctamin-2
Synonyms:
ANO2 | ANO2_HUMAN | Anoctamin-2 | C12orf3 | TMEM16B | Transmembrane protein 16B
Type:
PROTEIN
Mol. Mass.:
113968.03
Organism:
Homo sapiens
Description:
ChEMBL_117372
Residue:
1003
Sequence:
MATPGPRDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGESTRSSSVINNYLDANEPVSLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAEFLKIKVPTKKEMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMSSGSQHTNV
  
Inhibitor
Name:
BDBM50503433
Synonyms:
CHEMBL4462374 | US11274074, Comparative Example 19 [Chemical Formula 37]
Type:
Small organic molecule
Emp. Form.:
C17H12ClF5N2O3
Mol. Mass.:
422.734
SMILES:
Cc1cc(Cl)ccc1OC(F)(F)C(=O)N\N=C\c1ccccc1OC(F)(F)F
Structure:
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