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Target
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Ligand
BDBM542579
Substrate
n/a
Meas. Tech.
Bim Binding Assays (Mcl-1 TR-FRET Assays)
Ki
0.066±n/a nM
Citation
 Rescourio, G; Gonzalez Buenrostro, A; Brown, SP; Lizarzaburu, M; Medina, J; Jabri, SY; Sun, D; Simonovich, SP; Yan, X; Li, Y; Rew, Y Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists US Patent  US11274105 Publication Date 3/15/2022 
Target
Name:
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Synonyms:
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]/Bcl-2-like protein 11 [51-76] | Mcl-1 and BIM | Mcl-1/BIM
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Synonyms:
BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17896.13
Organism:
Homo sapiens (Human)
Description:
Q07820[171-327]
Residue:
157
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
  
Component 2
Name:
Bcl-2-like protein 11 [51-76]
Synonyms:
B2L11_HUMAN | BCL2L11 | BIM | Bcl-2-like protein 11 (51-76) | Bcl-2-like protein 11 (BIM) (51-76)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
2530.22
Organism:
Homo sapiens (Human)
Description:
O43521[51-76]
Residue:
26
Sequence:
EGDSCPHGSPQGPLAPPASPGPFATR
  
Inhibitor
Name:
BDBM542579
Synonyms:
(3R,6R,7S,11R,17R,24S)-6′-CHLORO-17-HYDROXY-14-METHYL-15-OXO-3′,4′-DIHYDRO-2′H-SPIRO[8,22-DIOXA-1,14-DIAZAPENTACYCLO[16.7.2.17,11.03,6.021,26]OCTACOSA-18,20,26-TRIENE-24,1′-NAPHTHALENE]-17-CARBOXYLIC ACID | US11274105, Example 69 | US11274105, Example 70
Type:
Small organic molecule
Emp. Form.:
C35H43ClN2O6
Mol. Mass.:
623.179
SMILES:
CN1CC[C@@H]2CCO[C@@H](C2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)[C@@](O)(CC1=O)C(O)=O |r|
Structure:
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