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Target
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Ligand
BDBM542678
Substrate
n/a
Meas. Tech.
Bim Binding Assays (Mcl-1 TR-FRET Assays)
Ki
0.042±n/a nM
Citation
 Rescourio, G; Gonzalez Buenrostro, A; Brown, SP; Lizarzaburu, M; Medina, J; Jabri, SY; Sun, D; Simonovich, SP; Yan, X; Li, Y; Rew, Y Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists US Patent  US11274105 Publication Date 3/15/2022 
Target
Name:
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Synonyms:
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]/Bcl-2-like protein 11 [51-76] | Mcl-1 and BIM | Mcl-1/BIM
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Synonyms:
BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17896.13
Organism:
Homo sapiens (Human)
Description:
Q07820[171-327]
Residue:
157
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
  
Component 2
Name:
Bcl-2-like protein 11 [51-76]
Synonyms:
B2L11_HUMAN | BCL2L11 | BIM | Bcl-2-like protein 11 (51-76) | Bcl-2-like protein 11 (BIM) (51-76)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
2530.22
Organism:
Homo sapiens (Human)
Description:
O43521[51-76]
Residue:
26
Sequence:
EGDSCPHGSPQGPLAPPASPGPFATR
  
Inhibitor
Name:
BDBM542678
Synonyms:
(1S,3′R,6′R,7′S,8′E,15′R)-6-CHLORO-N-(CYCLOPROPYLSULFONYL)-7′-(2-(3,3-DIFLUORO-1-AZETIDINYL)ETHOXY)-15′-HYDROXY-12′-METHYL-13′-OXO-3,4-DIHYDRO-2H-SPIRO[NAPHTHALENE-1,22′-[20]OXA[1,12]DIAZATETRACYCLO [14.7.2.03,6.019,24]PENTACOSA[8,16,18,24]TETRAENE]-15′-CARBOXAMIDE | US11274105, Example 177
Type:
Small organic molecule
Emp. Form.:
C41H51ClF2N4O7S
Mol. Mass.:
817.381
SMILES:
CN1CC\C=C\[C@H](OCCN2CC(F)(F)C2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)[C@](O)(CC1=O)C(=O)NS(=O)(=O)C1CC1 |r,t:4|
Structure:
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